基于天然产物的药物研发对创新中药研究的启示—TTD收录天然药物.docx

基于天然产物的药物研发对创新中药研究的启示 —TTD收录天然药物分析 陈修平 陆金健 郭佳杰 鲍娇琳 徐文珊 丁倩 王一涛 （中药质量研究国家重点实验室(澳门大学)，澳门大学中华医药研究院，澳门999078） 摘 要：天然产物一直是新药研发的重要源泉，创新中药研发是中药现代化、国际化的关键环节。但由于中药系统的复杂性，目前创新中药研发尚存在诸多困难和困惑。基于靶点的药物研发是药物发现的主要模式和手段。TTD (Therapeutic Target Database)是新加坡国立大学开发的治疗靶点数据库，除收录大量的药物靶点信息外，还包含了大量天然产物的相关信息。本文简单介绍了TTD，通过分析TTD中收录的天然来源的药物/化合物，探讨了对创新中药研发的启示。 关键词：靶点；治疗靶点数据库；天然产物；中药；新药研发 Inspirations from Natural Products Based Drug Research and Development for Chinese Medicine Research -Analysis of Natural Products Recoded in TTD CHEN Xiu-Ping, LU Jin-Jian, GUO Jia-Jie, BAO Jiao-Lin, XU Wen-Shan, DING Qian, WANG Yi-Tao (State Key Laboratory of Quality Research in Chinese Medicine (University of Macau), Institute of Chinese Medical Sciences, University of Macau, Macau 999078) : angPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEXXXPAGEX