复方四君子汤的化学成分和药理作用研究进展_纪云飞.pdfVIP

中草药 Chinese Traditional and Herbal Drugs 第 47 卷 第 5 期 2016 年 3 月 ·837· ·综 述· 复方四君子汤的化学成分和药理作用研究进展 纪云飞，王瑞君，李晓波* 上海交通大学药学院，上海 200240 摘 要：四君子汤为中医健脾益气的代表方剂，由人参、白术、茯苓、炙甘草 4 味药组成，具有调节胃肠道功能、增强免疫 力、促进癌细胞凋亡、抗衰老作用，其主要化学成分为皂苷、黄酮和多糖，该方多糖成分、药效物质基础研究较少。总结了 四君子汤的化学成分、药理作用研究进展，为深入研究四君子汤及其临床的合理应用提供参考。 关键词：四君子汤；调节胃肠道功能；增强免疫力；皂苷；黄酮 中图分类号：R284；R285 文献标志码：A 文章编号：0253 - 2670(2016)05 - 0837 - 07 DOI: 10.7501/j.issn.0253-2670.2016.05.026 Research progress on chemical constituents and pharmacological effects of Sijunzi Decoction JI Yun-fei, WANG Rui-jun, LI Xiao-bo School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China Abstract: Sijunzi Decoction (SJZD) is a classical prescription for curing spleen deficiency in traditional Chinese medicine, consisting of Ginseng Radix et Rhizoma, Atractylodes Macrocephalae Rhizoma, Poria, and Glycyrrhizae Radix et Rhizoma Praeparate cum Melle. Modern pharmacological experiments have proved that sponin, flavonoid, and polysaccharide are the most active ingredients in SJZD. SJZD has been used to regulate gastrointestinal function and enhance immunity ability. Effects on tumor cell apoptosis and anti-aging have also been reported. But few report on SJZD polysaccharide and its therapeutic basis research was found. This review is to give a comprehensive summary of information regarding the chemical constituents and pharmacological effects of SJZD to help us take the action for reasonable clinical utilization and further researches of SJZD. Key words: Sijunzi Decoction; regulation of gastrointestinal function; enhancement of immunity; sponin; flavonoid 四君子汤出自宋代《太平惠民和剂局方》[1]， 1 复方四君子汤化学成分研究 由人参、白术、茯苓和炙甘草 4 味药组成，具有健 四君子汤组方中的人参