浙江大学医学免疫学经典课件免疫9、13—B细胞.pptVIP

Lie Wang (汪洌）;;;B cell development in the bone marrow;Secreted Factors - CYTOKINES;Bone marrow stromal cell;B;;Development and migration of B cells (An overview);Stages of differentiation in the bone marrow are defined by Ig gene rearrangement;B cell receptor;B cell development is coupled with rearrangement of heavy-chain; B cell development is coupled with rearrangement of heavy-chain; B cell development is coupled with rearrangement of heavy-chain; B cell development is coupled with rearrangement of heavy-chain; B cell development is coupled with rearrangement of heavy-chain; B cell development is coupled with rearrangement of heavy-chain;Splicing of IgM and IgD RNA; B cell development is coupled with rearrangement of heavy-chain;;Evidence for allelic exclusion;Y;Allelic exclusion is needed for efficient clonal selection;Allelic exclusion is needed to prevent holes in the repertoire ;;;;B cell self tolerance: clonal deletion;Y;Receptor editing;Y;B-cell surface markers;1. BCR complex;Antigen receptor-mediated signal transduction in B cells;CD19/CD21/CD81complex CD21=CR2, C3dR, EB virus receptor CD19/CD21/CD81 interactions with complement associated with antigen play a role in antigen-induced B-cell activation. ;The role of the coreceptor in B cell activation;(1)CD40 interacts with CD40L (Th cell) (2)CD80(B7.1), CD86(B7.2) Expressed on activated B cells and other APCs (3)ICAM-1 （CD54）、LFA-1（CD11α/CD18)： mediate cell-cell interaction and co-stimulation ;CD20: function is unclear. It is suspected that it acts as a calcium channel in the cell membrane CD22：Inhibitory receptor with ITIM motif CD32 (Fc?RII)： Inhibitory receptor Cytokine receptors Complement Receptors Toll-like receptors MHC ;3. Subtype of B cells;;B-2 cells : conventional B cells Recirculating follicular B cells : circulate between LN follicles and blood mIg: IgM, IgD Produce IgG after antigenic stimulation in the presence of T helper cells ;B1