脉压变化对超容量负荷联合压力负荷复制兔心衰模型影响的研究.pdfVIP

广西医科大学学报 2009 Jun; 26 (3) jOURNAL OF GUANGXI MEDICAL UNJVERSITY ? 329 ? 脉压变化对超窑量负荷联合压力负荷复制兔心褒模型影晌的研究铮 武欣迎杨波A 包明威张艳张炳山革澈 (武汉大学人民医院心内科武汉 43006 1) 摘要 目的:探讨不同的主动脉根部脉压变化程度对越睿量负荷联合压力负荷制作家兔心衰模琐的影响。方法:该模型采用 刺破主动脉瓣使主动脉根部脉压升高采造成越容最负荷，两周后缩窄腹主动脉制造超压力负荷。 59 只家兔饺或动脉根部脉压 升高程度的不同分为 4 组 :A 组(50%-99%)( n 皿 34) ， B 缎 (100%-199%)( n =1日，C 组 (200%)( n 的，D 组(对照组) ( n =的 ω8 周时行心脏多普勒检测。结果:(1)C 组家兔在 10 周内全部死亡以2)与 0 组相比，8 周时超声显示 A ，B 组发窒收缩 末期内径均明显增大，射IfU.分数均显著降低川3)8 周后 B 组死亡数增加。结论: (1)越容量负荷联合压力负荷复制心褒模裂 时，脉压增大拖围应该控制在 50%-200%之间 ;(2)8 周时即可成功复制越容量负荷联合压力负荷的慢性心衰模型。 关键词 心力褒竭 p动物模型 p压力超负荷 F容量超负荷 中图分类号: R54 1. 6+ 1 文献标志码 :A 文意编号 :1005物930X(2009)03棚0329翩03 THE EFFECT OF PULSE PRESSURE CHANGE ON THE VOLU岛1E AND PRESSURE OVER- LOAD蛐INDUCED HEART FAILURE MODEL IN RABBITS Wu Xinying , Yang Bo. Bao Mingwei , et a1. (Department of Cardiology. Rcnmin Hospital of Wuhan Uni- versity , Wuhan 430061 China) Abstract Objective: To investigate the extent of pulse pressure changes on the production of rabbit model of heart failure by combined volume and pressure overload. Metbods: Fifit沪nine rabbits were divided into four groups by different pressure changes:Group A (50%-99%) (n =3的，日 000% -199%) (n 皿 15) ， C(200%) (n =4) , D (control group) (n =6). The aortic valve was punctured ,and the level of pulse pres- sure was matched to each of the required standards. After two weeks , coarctated abdominal aorta to 50%. After 8 weeks. the heart function was detected by Doppler. Results: (1) All rabbits in Group C died in 10 weeks; (2)As compared with Group D , showed that the left ventricular systolic diameter was significantly increased and ejection fraction(EF) was reduced in Groups A and B in 8 weeks; (3) After eight weeks. the number of deaths was increased in Group B. Conclusion: (1) When heart filure was induced by volume and pressure overload in rabbit. the range of augmentation in pulse pressure should be controlled in 50 % ......, 200 %; (2) Eight echocardiography were enough to induce this model of c