益母草活血化瘀化学成分与药理作用研究进展.PDFVIP

- 214 - Drug Evaluation Research 第 38 卷 第 2 期 2015 年 4 月 益母草活血化瘀化学成分与药理作用研究进展 * * 张 雪，宋玉琴，杨雨婷，熊 亮，彭 成 ，谢晓芳 成都中医药大学药学院 中药资源系统研究与开发利用省部共建国家重点实验室培育基地，四川 成都 611137 摘 要：益母草是一种活血化瘀的常用药，临床上常用于治疗月经不调、产后瘀痛、心血管疾病、血液病等。益母草中含有 生物碱、二萜、阿魏酸、挥发油、黄酮类、多糖等多种化学成分，其中发现生物碱类、二萜类、环形多肽类等与益母草活血 化瘀作用相关；其药理作用与改变血液流变学，改善微循环，改善心肌缺血，抗血栓等有关。综述益母草活血化瘀作用的物 质基础与作用机制研究进展，旨在促进对该中药的进一步研究，为新药研发提供依据。 关键词：益母草；活血化瘀；化学成分；药理作用 中图分类号：R285 文献标志码：A 文章编号：1674-6376 (2014) 02-0214-04 DOI: 10.7501/j.issn.1674-6376.2014.02.021 Research progress on chemical components of Leonurus japonicus and their pharmacological effects of activating blood and resolving stasis ZHANG Xue, SONG Yu-qin, YANG Yu-ting, XIONG Liang,PENG Cheng, XIE Xiao-fang State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China Abstract: Leonurus japonicus is a common drug used in activating blood and resolving stasis, clinically used to treat irregular menstruation, postpartum blood stasis pain, cardiovascular disease, blood disease, etc. There are alkaloids, diterpene, ferulic acid, volatile oil, flavonoid, polysaccharide, and other chemical components in L .japonicus . Researchers found that alkaloids, diterpenoid, and circular peptide are associated with blood circulation of L .japonicus ; The pharmacological effects are related to changing blood rheology, improving microcirculation, improving myocardial ischemia, anti-platelet aggregation, and so on. Overviewing the research progress on the material basis and its mechanism of activating blood and resolving stasis. This paper aims at promoting the further research and development of Chinese mat