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Knee contact forces are not altered in early knee osteoarthritis.pdf

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Knee contact forces are not altered in early knee osteoarthritis.pdf

Gait Posture 45 (2016) 115–120 Contents lists available at ScienceDirect Gait Posture journal homepage: /locate/gaitpost Knee contact forces are not altered in early knee osteoarthritis S. Meireles MEa,*, F. De Groote PhDb, N.D. Reeves PhDc, S. Verschueren PhDd, C. Maganaris PhDe, F. Luyten PhDf, I. Jonkers PhDa a Department of Kinesiology, KU Leuven, Belgium b Department of Mechanical Engineering, KU Leuven, Belgium c School of Healthcare Science, Manchester Metropolitan University, United Kingdom d Department of Rehabilitation Sciences, KU Leuven, Belgium e School of Sport and Exercise Sciences, Liverpool John Moores University, United Kingdom f Department of Development and Regeneration, KU Leuven, Belgium ARTICLE INFO Article history: Received 16 July 2015 Received in revised form 11 December 2015 Accepted 17 January 2016 Keywords: Knee osteoarthritis Knee contact forces Musculoskeletal model Gait ABSTRACT Objective: This study calculated knee contact forces (KCF) and its relations with knee external knee adduction moments (KAM) and/or ?exion moments (KFM) during the stance phase of gait in patients with early osteoarthritis (OA), classi?ed based on early joint degeneration on Magnetic Resonance Imaging (MRI). We aimed at assessing if altered KCF are already present in early structural degeneration. Design: Three-dimensional motion and ground reaction force data in 59 subjects with medial compartment knee OA (N = 23 established OA, N = 16 early OA, N = 20 controls) were used as input for a musculoskeletal model. KAM and KFM, and KCF were estimated using OpenSim software. Results: No signi?cant differences were found between controls and subjects with early OA. In early OA patients, KAM signi?cantly explained 69% of the variance associated with the ?rst peaks KCF but only KFM contributed to the second peaks KCF. The multiple correlation, combining KAM and KFM, showed to be higher. However, only 20% of the variance of second peak KCF was explained by both moment