Extended wear therapeutic contact lens fabricated from timolol imprinted carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-poly acrylamide as a onetime medication for glaucoma.pdfVIP

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Extended wear therapeutic contact lens fabricated from timolol imprinted carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-poly acrylamide as a onetime medication for glaucoma.pdf

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Extended wear therapeutic contact lens fabricated from timolol imprinted carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-poly acrylamide as a onetime medication for glaucoma.pdf

European Journal of Pharmaceutics and Biopharmaceutics 109 (2016) 61–71 Contents lists available at ScienceDirect European Journal of Pharmaceutics and Biopharmaceutics journal homepage: /locate/ejpb Research paper Extended wear therapeutic contact lens fabricated from timolol imprinted carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-poly acrylamide as a onetime medication for glaucoma T.S. Anirudhan ?, Anoop S. Nair, J. Parvathy Department of Chemistry, School of Physical and Mathematical Sciences, University of Kerala, Kariavattom, Trivandrum 695 581, India article info Article history: Received 7 June 2016 Revised 19 August 2016 Accepted in revised form 17 September 2016 Available online 20 September 2016 Keywords: Therapeutic contact lenses Molecular imprinting Carboxymethyl chitosan Timolol abstract An extended wear therapeutic contact lens (TCL) for the sustained delivery of timolol maleate (TML) was fabricated based on molecular imprinting technique. The designed TCL comprised of a TML imprinted copolymer of carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-polyacrylamide (CmCS-gHEMA-g-pAAm) embedded onto a poly HEMA matrix (pHEMA). Successful reloading of TML onto the lens was monitored using a simple and novel UV–Visible spectrophotometric method which showed an excel- lent reloading capacity of 6.53 lg TML/TCL. The in vitro drug release pro?le in lacrimal ?uid after each cycle was ?tted onto Higuchi model of drug release suggesting diffusion release mechanism with no polymer degradation. Also, the TML release kinetics indicated a sustained drug delivery which can effectively achieve the therapeutic index of TML leading to a onetime medication for glaucoma. Biological activity of eluted drug after each cycle and cell viability of the TCL were veri?ed using 2,2-diphenyl-1picrylhydrazyl (DPPH) and 2,3-bis(2-methoxynitro-5-sulfophenyl)-5-(phenylaminocarbonyl)-2H-tetrazo lium hydroxide (XTT) assay, respectively. ó 2016 Elsevier B.V. All rights reserve