Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System.pdfVIP

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Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System.pdf

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Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System.pdf

Communication Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System Ralf M. Zerbes 1, 2, Philipp H?? 1, Nikolaus Pfanner 1, 3, Martin van der Laan 1, 3, 4, and Maria Bohnert 1, ? 1 - Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany 2 - Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany 3 - BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany 4 - Medical Biochemistry and Molecular Biology, Saarland University, 66421 Homburg, Germany Correspondence to Nikolaus Pfanner and Martin van der Laan: Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany; Medical Biochemistry and Molecular Biology, Saarland University, 66421 Homburg, Germany. nikolaus.pfanner@biochemie.uni-freiburg.de; martin.van-der-laan@uks.eu /10.1016/j.jmb.2016.02.031 Edited by Dr. M Yaniv Abstract The mitochondrial inner membrane consists of two morphologically distinct domains, the inner boundary membrane and large invaginations termed cristae. Narrow membrane structures, the crista junctions, link these two domains. Maintenance of this elaborate architecture depends on the evolutionarily conserved mitochondrial contact site and cristae organizing system (MICOS), a multisubunit inner membrane protein complex. MICOS consists of two functional modules, a Mic60–Mic19 subcomplex that forms Mic60-mediated contact sites with the outer mitochondrial membrane and a Mic10–Mic12–Mic26–Mic27 membrane-sculpting subcomplex that contains large Mic10 oligomers. Deletion of MIC10 or MIC60 results in the loss of most crista junctions. Distinct views have been discussed about how the MICOS modules cooperate with each other. We searched for components required for the structural organization of MICOS and identified Mic12 and Mic27 as crucial factors with specific roles in MICOS