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Broad spectrum antibiotic enrofloxacin modulates contact sensitivity through gut microbiota in a murine model.pdf

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Broad spectrum antibiotic enrofloxacin modulates contact sensitivity through gut microbiota in a murine model.pdf

Broad spectrum antibiotic enro?oxacin modulates contact sensitivity through gut microbiota in a murine model Anna Strze? pa, PhD,a Monika Majewska-Szczepanik, PhD,a Francis M. Lobo, MD,b Li Wen, MD, PhD,c and Marian Szczepanik, PhDa Krakow, Poland, and New Haven, Conn GRAPHICAL ABSTRACT From athe Department of Medical Biology, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow; bthe Section of Allergy and Clinical Immunology, and cthe Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven. Supported by grants from National Science Center in Poland (2011/01/B/NZ6/00300 and K/ZDS/004650 to M.S.) and National Institutes of Health (DK088181 and DK092882 to L.W., and K/DSC/002879 to A.S.). Disclosure of potential con?ict of interest: A. Strze?pa has received a grant from Ministerstwo Nauki i Szkolnictwa Wyz_szego. L. Wen has received a grant from the National Institute of Health. M. Szczepanik has received grants from Ministerstwo Nauki i Szkolnictwa Wyz_szego and the National Science Centre. The rest of the authors declare that they have no relevant con?icts of interest. Received for publication January 10, 2016; revised November 10, 2016; accepted for publication November 23, 2016. Corresponding author: Marian Szczepanik, PhD, Department of Medical Biology, Jagiellonian University Medical College, ul. Kopernika 7a, 31-034 Krakow, Poland. E-mail: mmszczep@.pl. Or: Li Wen, MD, PhD, Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520-8013. E-mail: li.wen@. 0091-6749/$36.00 ó 2017 American Academy of Allergy, Asthma Immunology /10.1016/j.jaci.2016.11.052 1 2 STRZE? PA ET AL J ALLERGY CLIN IMMUNOL nnn 2017 Background: Medical advances in the ?eld of infection therapy have led to an increasing use of antibiotics, which, apart from eliminating pathogens, also partially eliminate naturally existing commensal bacteria. It has b