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Allergic Contact Dermatitis from Topical Acyclovir Case Series.pdf
The Journal of Emergency Medicine, Vol. 52, No. 2, pp. e37–e39, 2017 ó 2016 Elsevier Inc. All rights reserved. 0736-4679/$ - see front matter
/10.1016/j.jemermed.2016.07.083
Clinical Communications: Adult
ALLERGIC CONTACT DERMATITIS FROM TOPICAL ACYCLOVIR: CASE SERIES
Anca Chiriac, MD, PHD,*? Anca E. Chiriac,? Tudor Pinteala,? Cosmin Moldovan, MD, PHD,§ and Simona Stolnicu, MD, PHDk
*Department of Dermatology, Nicolina Medical Center, Iasi, Romania, ?Department of Dermato-Physiology, Apollonia University, Iasi, Romania, ?‘‘Gr. T. Popa’’ University of Medicine and Pharmacy, Iasi, Romania, §Department of Histology, and kDepartment of Pathology,
University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania Reprint Address: Cosmin Moldovan, MD, PHD, Department of Histology, University of Medicine and Pharmacy of Tirgu Mures, 38 Gheorghe
Marinescu Street, Tirgu Mures 540139, Romania
, Abstract—Background: Despite the widespread use of oral or topical acyclovir, allergic contact dermatitis caused by it has been rarely reported, with fewer than 20 case studies published in the English literature to date. Case Reports: A diagnosis of allergic contact dermatitis from acyclovir cream was established in a 62-year-old female patient who had been continuously using acyclovir cream for 3 weeks after systemic therapy for herpes zoster with acyclovir, and in a 35-year-old female patient, who had undergone liver transplantation in 2008 and subsequently developed a severe form of herpes zoster treated orally with 4 g/day acyclovir and prolonged topical administration of acyclovir cream. In both cases, patch tests were performed with extended European Baseline Series, with the excipients of acyclovir cream (propylene glycol, sodium lauryl sulfate, cetostearyl alcohol, dimethyl sulfoxide) and commercial cream containing acyclovir 2%. Positive reactions were obtained only with the commercial cream with acyclovir 2%. Why Should an Emergency Physician Be Aware of This?: Allergi
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