[第十八章治疗药物浓度监测.pptVIP

第十八章治疗药物浓度监测 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. KEY POINTS Therapeutic drug monitoring is by measuring the level of some drugs as a way to determine the most effective dose or to avoid toxicity. Most drugs do not need to be monitored this way because doctor can use another test (like blood pressure, temperature, or glucose) to tell if the dose is right. The drugs that are monitored have some special features: most of them work best over a small range – below this range, the drug is not effective and the patient begins having symptoms again; above this range, the drug has bad or toxic side effects . Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Major Objectives 掌握治疗药物监测的定义；药物在体内代谢的过程；血药浓度的影响因素；TDM的临床应用；治疗药物监测的临床应用。 熟悉房室模型及消除动力学模型；TDM的药效学与药动学。 重点TDM的定义、性质；药物在体内的基本过程及对血药浓度的影响。TDM常用标本种类，取样时间确定原则及常用预处理方法。 难点房室模型及消除动力学模型，表观分布容积的概念及意义。TDM的临床应用及根据TDM结果调整剂量的方法. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Brief Contents 第一节 概论 第二节 药物代谢动力学基础及有关参数的应用 第三节 治疗药物浓度监测的依据与临床应用 第四节 治疗药物监测标本及预处理 第五节 药物浓度测定常用技术评价 第六节 进行浓度监测的主要药物 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. 治疗药物监测（therapeuticdrugmonitoring，TDM）是自本世纪60年代起，在临床药理学、药代动力学和临床化学基础上，结合现代分析检测技术，形成和发展的一门应用性边缘学科。 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. 第一节 概论 一、药物的体内过程 二、血药浓度与药物效应 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. 一、药物的体内过程 l. 生物膜对药物的转运 (1)主动转运 (2)被动转运 2. 吸收 3. 分布 4. 生物转化 5. 排泄 二、血药浓度与药物效应 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0