abstract-2.docVIP

Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients The theory basis of this study from so background that Adipokines are peptide hormones or cytokines secreted from adipose tissues and involved in the pathogenesis of metabolic syndrome.At the same time,psoriasis patients have a high prevalence of the metabolic syndrome MS ,and MS has been reported to be associated with an increased risk of psoriasis, however,the impact of adipokines on the psoriatic etiology remains unsolved.While Th17-related cytokines are also involved in the pathogenesis of psoriasis.It is the epidemiological and material reason that author set about doing the research.The purpose of study is that exploreing the Kinetics of circulating Th17 cytokines and adipokines and their correlation with PASI in psoriasis patients. The methods of this study is designed as follows:Fasting serum samples were obtained from psoriasis patients n? ?30 , sex- and weight-matched control subjects n? ?30 ,and analyzed by enzyme-linked immunosorbent assay method.The serum chemistry and complete blood count tests were performed.Weight, height, body mass index BMI ,and waist circumferences of all the individuals were recorded.Disease severity was assessed with the Psoriasis Area and Severity Index PASI by the same physician. In this study,researcher investigated the statistics of circulating Th17-related cytokines and adipokines in psoriasis patients.they identified the significant elevation of serum IL-6, IL-21, IL-22, and resistin levels in psoriasis patients.Increased serum levels of IL-22 and adiponectin were positively correlated with Psoriasis Area and Severity Index PASI .In contrast,serum high molecular weight adiponectin levels were decreased in psoriasis and negatively correlated with PASI. They have also investigated alternation of circulating cytokines TNF-α, IL-6, IL-17, IL-21, IL-22, and IL-23 and adipokines retinol-binding protein-4: RBP-4, resistin, chemerin, and leptin; a