多模式成像与治疗光热治疗精讲.pptVIP

多模式成像与治疗 ——光热治疗 2013-11-01 光热治疗是治疗肿瘤的一种新技术，其过程是，首先肿瘤组织选择性摄取光敏剂，并储于其内，随后使用穿透性好的激光（通常使用近红外光），可穿透皮下深层组织，而且近红外波长范围是生物组织具有的光学窗口，是肌体组织的安全透射窗口，所以人体自身对近红外光的穿透能力较强，主要组成成分如水等对近红外光的吸收能力较差。由此，近红外光不会对周围正常组织和细胞产生影响，可直接应用于皮下深层组织（10cm左右）肿瘤的近红外光热疗，近红外光选择性照射肿瘤组织，其区域产生热量，温度升高，导致癌细胞死亡。因此，新型高效光热治疗的生物医学材料在肿瘤治疗中具有重要意义。 Photothermal therapy (PTT) is able to burn cancer through converting near-infrared (NIR) light energy into heat by using NIR-absorbing agents. Compared with traditional cancer treatment methods such as radiotherapy and chemotherapy,PTT is highly effective in tumor ablation and exhibits minimal damage to normal tissues. Imaging-guided therapy 成像能提供有关肿瘤的位置，大小，形状等可用的信息，是保证整个肿瘤有效地暴露于光在PTT治疗中所必需的。 为了达到最高的光热消融效果，必须使近红外激光照射时所适用的光热剂到达肿瘤中的积累量最高。实时跟踪的光热剂是达到最佳疗效的重要步骤。 光热治疗的纳米材料分为三种 ： 1、传统的有机化合物，如吲哚菁绿，聚苯胺。缺点是低光热转换率和严重光漂白。2、碳纳米材料，如碳纳米管，石墨烯，还原性石墨烯。 3、贵金属纳米材料，如gold nanoshells nanorods，nanocages，hollow nanospheres。 Ultra-Small Iron Oxide Doped Polypyrrole Nanoparticles for In Vivo Multimodal Imaging Guided Photothermal Therapy Xuejiao Song , Hua Gong , Shengnan Yin , Liang Cheng , Chao Wang , Zhiwei Li ,Yonggang Li , Xiaoyong Wang , Gang Liu , and Zhuang Liu Adv. Funct. Mater. 2013,DOI:10.1002/adfm.201302463 c) Growth of 4T1 tumors in different groups of mice after various treatments indicated. The relative tumor volumes were normalized to their initial sizes. For the treatment group, six mice injected with IONP@PPy-PEG at 24 h post injection were exposed to the 808-nm laser The other three groups of mice with six mice per group were used as controls: untreated; laser only;injected with IONP@PPy-PEG but without laser irradiation. d) Survival curves of mice after various treatments indicated. IONP@PPy-PEG injected mice after PTT treatment showed 100% survival ratio over 40 days. Folate-conjugated Fe3O4@SiO2@gold nanorods@mesoporous SiO2 hybrid nanomaterial: a theranostic agent for magnetic resonance imaging and photothermal therapy J. Mater. Chem. B, 2013, 1, 2934–2942 D