Functions - 河南大学精品课程网.ppt

维生素与辅酶 contents To promote blood coagulation; Important factors in hepatic synthesis of thrombinogen and other blood coagulation factors . Deficiency : anaemia Sources: Green vegetables. Intestinal microorganisms FMN∶ Flavin mononucleotide黄素单核苷酸 FAD∶Flavin Adenine Dinucleotide黄素腺嘌呤二核苷酸 FMN, FAD——prosthetic groups——tightly bind to enzyme Yellow →flavoprotein Strong oxidant that is reduced by 1 or 2 atoms: H transfer Functions： Promote saccharide, lipid and protein metabolism as prosynthetic group. Protect mucosa, maintain visual function, promote growth. Deficiency: Weak respiratory system, low metabolism rate angular cheilitis(口角炎), glossitis(舌炎), conjunctivitis(结膜炎). Min intake for adults: 1.6mg/d No intoxication when overdosed. Sources: Wide existence in plants Rice bran, yeast, liver, yolk, etc.. Acidic compound of α, γ-dihydroxyl-β, β-dimethylbutyric acid β-alanine phosphonic acid pantothenic acid β-cysteamine ↓ 4′-phosphopantetheine (4′-P-PaSH) + 5′-adenylate-3′- phosphonic acid ↓ CoA-SH (辅酶A） Sulfatidate bond faciliates hydrolization 3.3 Pantothenic acid (Vit. B3) CoA-SH Participate in saccharide, lipid and protein metabolism in the form of CoA-SH Participate in fatty acid metabolism as prosynthetic group of acyl carrier protein Acyl carrier of acylation and oxydation decarboxylation（acyl- CoA：saccharide and lipid oxidation. Synthesis of acetylcholine, cholesterol, glycogen, modulates blood lipid. Effective to anorexia and debilitation Ancillary drug for hepatitis and coronary heart disease Functions: Wide existence. Liver, kidney, wheat, rice bran, yeast peanut. Sources: pellagra preventive factor or VPP Nicotinic Acid(烟酸) Nicotinamide(烟酰胺) 4. Nicotinic Acid and CoⅠ,CoⅡ Oxidized form Reduced form NAD+ NADH energy yielding catabolism oxidized by respiratory chain NADP+