Celebrating60YearsofCaring-NationalHemophilia.pptVIP

Celebrating 60 Years of Caring NHF Nursing Luncheon November 14, 2008 Jim Munn, RN, MS Hemophilia: Early Observations- Second Century Early Observations Tenth Century Islamic Surgeon Abul Qasim Al-Zahravi (Albucasis) 936-1013 CE Considered greatest surgeon of Middle Ages Referred to a condition interpreted by scholars as hemophilia in his encyclopedic work on medicine and surgery, al-Tasrif Early Observations “If a woman had her first son circumcised and he died as a result of the circumcision, which enfeebled his strength, and she similarly had her second [son] circumcised and he died as a result of the circumcision - whether [the latter child] was from her first husband or her second husband - the third son may not be circumcised at the proper time [on the eighth day of life]…”2 Early Observations 1803: John Conrad Otto Provided first accurate account of hemophilia in the modern medical literature His investigation of “bleeders” was published in a New York journal under the title, “An Account of an Hemorrhagic Disposition Existing in Certain Families” Traced to woman who settled in Plymouth, New Hampshire in 1720 Early Observations 1820: Nasse of Bonn German physician 1778-1851 Formulated observations on inheritance of hemophilia “Nasse’s Law” Transmitted by unaffected females to their sons Early Observations 1828: The word “hemophilia” first appears in a description of inherited bleeding disorders by Physician Frederick Hopff at the University of Zurich 1840: First recorded case of hemophilia treatment by transfusion written by Samuel Lane in The Lancet 1 1893: First documentation of abnormal prolongation of coagulation in capillary tube in hemophilics2 Early Observations: Other Highlights of the Early 1900s 1911: Publication of “monumental review of pedigrees of families with bleeding disorders”1 1920-1930: Hemophilia treatments published; plasma for transfusions introduced 1926: Erik vonWillebrand describes bleeding disorder affecting both se