Prevention effects of Schisandra polysaccharide on radiation-induced immune system dysfunction》.pdfVIP

Prevention effects of Schisandra polysaccharide on radiation-induced immune system dysfunction》.pdf

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Prevention effects of Schisandra polysaccharide on radiation-induced immune system dysfunction》.pdf

International Journal of Biological Macromolecules 76 (2015) 63–69 Contents lists available at ScienceDirect International Journal of Biological Macromolecules j o u r na l h o me p a g e : w w w. elsev /locate/ijbiomac Prevention effects of Schisandra polysaccharide on radiation-induced immune system dysfunction Lian-Mei Zhao a , Yun-Long Jia b , Ming Ma a , Yu-Qing Duan b , Li-Hua Liu b,∗ a Research Centre, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, PR China b Department of Biotherapy, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050035, PR China a r t i c l e i n f o a b s t r a c t Article history: In this study, we investigate the efficacy of SP (Schisandra polysaccharide) in prevention of radiation- Received 21 October 2014 induced immune dysfunction and discussed the underlying mechanisms with a Bal/bc mouse model. The Received in revised form 21 January 2015 data demonstrated that SP could reverse the decreases in the number of white blood cells and lympho- Accepted 12 February 2015 cytes in peripheral blood. In addition, the immunoglobulin G (IgG) and complement C3 in blood serum Available online 20 February 2015 were all decreased after radiation and SP could restore this radiation disorder. Furthermore, SP could + + + + reverse the deregulation of CD3 CD4 and CD3 CD8 T cell subsets in peripheral blood and thymus of Keywords:

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