Physiological studies of brainstem reticular connectivity. I. Responses of mPRF neurons to stimulation of bulbar reticular formation》.pdfVIP

Brain Research, 409 (1987) 97-110 97 Elsevier BRE 12502 Physiological studies of brainstem reticular connectivity. I. Responses of mPRF neurons to stimulation of bulbar reticular formation Kelhachlro Ito and Robert W McCarley Nearoscleme Laborator~ Department of Psychiatry Harvard h4edwal School and Brockton VAMC. Brocl~ton. 4/IA 02401 ( U ~ A ) (Accepted 2 September 1986) Key ~ords Intracellular recording Bralnstem connecu~t} Medial pontlne reticular formation, Bulbar reticular formation The connectivity between medial pontlne reticular formation (mPRF) and bulbar reticular formation (BRF) was studied by Intra- cellular recordings of mPRF neuronal responses to mlcrostlmulatlon of BRF in unanesthetized, undrugged cats There was a very high percentage (75-90%) of monosynaptIc latency postsynaptlc potentials (PSPs) in mPRF neurons in response to mlcrostimulatlon of 3 BRF areas the magnocellular tegmental field (FTM), the bulbar glgantocellular tegmental field (BFTG), and bulbar lateral tegmen- tal field (BFTL) The type of initial orthodromic response produced in mPRF neurons by BRF stimulation was predominantly (75-95%) a monosynaptic excitatory PSP (EPSP) which was characterized by a rapid rise time, a nearly constant latency, and often led to spike potential generation In contrast, the percentage of initml monosynaptic inhibitory PSPs (IPSPs) was much lower for FTM (12 3%), for BFFG (12 5%) and was zero for BFFL While microstlmulation t