Plasma lipoproteins in infantile visceral Leishmaniasis deficiency of apolipoproteins A-I and A-II》.pdf

181 Clinica Chimica Actu, 184 (1989) 181-192 Elsevier CCA 04537 Plasma lipoproteins in infantile visceral Leishmaniasis: deficiency of apolipoproteins A-I and A-II Etienne D. Bekaert ‘, Rekaya Kallel 2, Marie-Elisabeth Bouma 3, Jean-Fraqois Lontie 4, Abderraouf Mebazaa 2, Claude L. ~almendier 4 and Marise Ayrault-Jarrier ’ ’ Unitk de Recherches SW les DysfipidPmies et l’Athosciose, INSERM U32, Gpital Henri Mondor, CtPteil Ckdex (France), 2 Laboratoire de Biochimie, H6pital LA Rabta, Tunis (Tunisia), ’ Laboratoire de Biologie celiulaire, INSERM U24, Paris (France) and ’ Fondation de Recherche sur l’Athrasclose, Brussels (Belgium) (Received 26 November 1988; revision received 10 May 1989; accepted 2 June 1989) Key words: Infantile visceral Leishmaniasis; Apolipoprotein A-I; Apolipoprotein A-II; Apolipoprotein B; Plasma lipoprotein; Gel permeation chromatography; Two-dimensional immunoelectrophoresis Summa~ This study describes the plasma lipoprotein system of young children with visceral Leishmaniasis (Kala-azar disease). In addition to the presence of amastigote forms in the sternal aspirates of bone marrow, the patients exhibited fever, anemia, hepatosplenomegaly, various degrees of pancytopenia and a slight liver cytolysis. Patients had normal total cholesterol levels and increased triglyceride levels in the p