Orientia, rickettsia, and leptospira pathogens as causes of CNS infections in Laos a prospective study》.pdf

Articles Orientia, rickettsia, and leptospira pathogens as causes of CNS infections in Laos: a prospective study Sabine Dittrich, Sayaphet Rattanavong, Sue J Lee, Phonepasith Panyanivong, Scott B Craig, Suhella M Tulsiani, Stuart D Blacksell, David A B Dance, Audrey Dubot-Pérès, Amphone Sengduangphachanh, Phonelavanh Phoumin, Daniel H Paris, Paul N Newton Summary Background Scrub typhus (caused by Orientia tsutsugamushi), murine typhus (caused by Rickettsia typhi), and Lancet Glob Health 2015; leptospirosis are common causes of febrile illness in Asia; meningitis and meningoencephalitis are severe 3: e104–12 complications. However, scarce data exist for the burden of these pathogens in patients with CNS disease in endemic See Comment page e67 countries. Laos is representative of vast economically poor rural areas in Asia with little medical information to guide Lao-Oxford-Mahosot Hospital- public health policy. We assessed whether these pathogens are important causes of CNS infections in Laos. Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Methods Between Jan 10, 2003, and Nov 25, 2011, we enrolled 1112 consecutive patients of all ages admitted with CNS