Novel microcatheter-based intracarotid delivery approach for MCAOR mice》.pdfVIP

Neuroscience Letters 597 (2015) 127–131 Contents lists available at ScienceDirect Neuroscience Letters j o u rn al h omepage: w w w. elsev /locate/neulet Research article Novel microcatheter-based intracarotid delivery approach for MCAO/R mice Qiang Cai a,b , Zhibiao Chen a , Derek Kai Kong b , Jun Wang a , Zhou Xu a , Baohui Liu a , Qianxue Chen a,∗ , Jiangbing Zhou b a Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan City, Hubei Province, 430060, China b Department of Neurosurgery, Yale University, 333 Cedar Street, FMB 410, New Haven, CT 06520, USA h i g h l i g h t s • It is a novel model to study stroke in mice. • It is the first time to combine the two techniques in mice. • It is the first time to describe and classify the variation of occipital artery in mice. a r t i c l e i n f o a b s t r a c t Article history: The intra-arterial (IA) model by microcatheter administration was an effective way to deliver drugs or cells Received 3 February 2015 to the brain. All of these models were carried out introduced in rat rather than mice for the difficult and Received in revised form 15 April 2015 technically challenging due to their small caliber. In 2014, Alejandro Santillan first introduced this model Accepted 17 April 2015 in mice and we found that most of the operational steps were similar with the middle cerebral artery Available online 18 April 2015 occlusion and reperfusion (MCAO/R) model. We attempted to combine these two technique