NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells》.pdfVIP

Toxicology and Applied Pharmacology 286 (2015) 80–91 Contents lists available at ScienceDirect Toxicology and Applied Pharmacology journal homepage: /locate/ytaap NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells Wei-Xia Duan a, Min-Di He a,1, Lin Mao a, Feng-Hua Qian b, Yu-Ming Li c, Hui-Feng Pi a, Chuan Liu a, Chun-Hai Chen a, Yong-Hui Lu a, Zheng-Wang Cao a, Lei Zhang a, Zheng-Ping Yu a, Zhou Zhou a,⁎ a Department of Occupational Health, Third Military Medical University, Chongqing 400038, Peoples Republic of China b Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, Peoples Republic of China c Institute of Hepatobiliary Surgery, XinQiao Hospital, Third Military Medical University, Chongqing 400038, Peoples Republic of China a r t i c l e i n f o a b s t r a c t Article history: With application of nano-sized nickel-containing particles (Nano-Ni) expanding, the health concerns about their Received 25 January 2015 adverse effects on the pulmonary system are increasing. However, the mechanisms for the pulmonary toxicity of Revised 20 March 2015 these materials remain unclear. In the present study, we focused on the impacts of NiO nanoparticles (NiONPs) Accepted 21 March 2015 on sirtuin1 (SIRT1), a NAD-dependent deacetylase, and investigated whether SIRT1 was involved in NiONPs- Available online 1 April 2015 induced apoptosis. Although the NiONPs tended to a