Low serum concentration of apolipoprotein A-I is an indicator of poor prognosis in cirrhotic patients with severe sepsis》.pdfVIP

Journal of Hepatology 50 (2009) 906–915 /locate/jhep Low serum concentration of apolipoprotein A-I is an indicator of poor prognosis in cirrhotic patients with severe sepsisq 1,6 2 3,6 1,6 Ming-Hung Tsai , Yun-Shing Peng , Yung-Chang Chen , Jau-Min Lien , Ya-Chung Tian3,6 3,6 4 1,6 , Ji-Tseng Fang , Hsu-Huei Weng , Pang-Chi Chen , Chih-Wei Yang3,6, Cheng-Shyong Wu5,6,* 1Division of Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan 2Division of Endocrinology, Chang Gung Memorial, Hospital, Chia-Yi, Taiwan 3Division of Critical Care Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan 4Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chia-Yi, Taiwan 5Division of Gastroenterology, Chang Gung Memorial Hospital, Chia-Yi, Taiwan 6 Chang Gung University, College of Medicine, Tao-Yuan, Taiwan Background/Aims: Severe sepsis is frequently associated with hypocholesterolemia which is also a common finding in cir- rhotic patients. Lipoprotein is capable of binding endotoxin to which cirrhotic patients exhibit an excessive pro-inflamma- tory response. Methods: We evaluated the relationship between lipid levels, inflammatory