Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis》.pdfVIP

Biochimica et Biophysica Acta 1842 (2014) 2204–2215 Contents lists available at ScienceDirect Biochimica et Biophysica Acta j ournal homepage: www.el sevier. com/l ocate/ bb adis Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis Yong He, Yu-ting Wu, Cheng Huang, Xiao-Ming Meng, Tao-tao Ma, Bao-Ming Wu, Feng-yun Xu, Lei Zhang, Xiong-Wen Lv, Jun Li ⁎ School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China The Key Laboratory of Anti-infl ammatory and Immune Medicine, Anhui Medical University, Ministry of Education, Hefei 230032, China Institute for Liver Diseases of Anhui Medical University, ILD-AMU, Anhui Medical University, Hefei 230032, China a r t i c l e i n f o a b s t r a c t Article history: Long noncoding RNAs (lncRNAs) are being increasingly recognized as major players in governing fundamental Received 12 May 2014 biological processes through diverse mechanisms. Maternally expressed gene 3 (MEG3) is an imprinted gene Received in revised form 1 August 2014 located at 14q32 that encodes a lncRNA correlated with several human cancers. Recently, the methylation- Accepted 28 August 2014 dependent downregulation of MEG3 has been described in liver cancers. However, its biological functional role Available online 6 September 2014 in liver fibrosis remains unknown. In our study, MEG3 levels were remarkably decreased in CCl4-induced mouse liver fibro