Liver-directed gene therapy of chronic hepadnavirus infection using interferon alpha tethered to apolipoprotein A-I》.pdfVIP

Research Article Liver-directed gene therapy of chronic hepadnavirus infection using interferon alpha tethered to apolipoprotein A-I 1,⇑ 1 2 2 1 Pedro Berraondo , Marianna Di Scala , Kyle Korolowicz , Linta M. Thampi , Itziar Otano , 1 1 1 1 2 Lester Suarez , Jessica Fioravanti , Fernando Aranda , Nuria Ardaiz , Junming Yang , 3 4 1 2, 1, Bhaskar V. Kallakury , Robin D. Tucker , Marcos Vasquez , Stephan Menne , Jesús Prieto , Gloria González-Aseguinolaza1, 1Division of Hepatology and Gene Therapy, Center for Applied Medical Research, University of Navarra, Pamplona, Navarra, Spain; 2Department of Microbiology Immunology, Georgetown University Medical Center, Washington, DC, USA; 3Department of Pathology, Georgetown University Medical Center, Washington, DC, USA; 4Division of Comparative Medicine, Georgetown University Medical Center, Washington, DC, USA Background Aims: Current hepatitis B virus (HBV) manage- a slight reduction of viremia which was associated with hemato- ment is challenging as treatment with nucleos(t)ide analogues logical toxicity and high mortality when using AAV-wIFN, while needs to be maintained indefinitely and because interferon AAV-wIA was well tolerated. However, when we tested (IFN)-a therapy is associated