Globostelletins A–I, cytotoxic isomalabaricane derivatives from the marine sponge Rhabdastrella globostellata》.pdfVIP

Bioorganic Medicinal Chemistry 18 (2010) 4639–4647 Contents lists available at ScienceDirect Bioorganic Medicinal Chemistry journal homepage: /locate/bmc Globostelletins A–I, cytotoxic isomalabaricane derivatives from the marine sponge Rhabdastrella globostellata Jin Li a, Bo Xu a, Jinrong Cui a, Zhiwei Deng b, Nicole J. de Voogd c, Peter Proksch d, Wenhan Lin a,* a State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People’s Republic of China b Analytical and Testing Center, Beijing Normal University, Beijing 100075, People’s Republic of China c National Museum of Natural History, PO Box 9517, 2300 RA Leiden, The Netherlands d Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Düsseldorf D-40225, Germany a r t i c l e i n f o a b s t r a c t Article history: Nine new isomalabaricane-derived natural products, globostelletins A–I (1–9), were isolated from the Received 10 March 2010 marine sponge Rhabdastrella globostellata, together with jaspolides F (10), rhabdastrellic acid-A (11), Revised 9 May 2010 ()-stellettin E (12), stellettins C (13) and D (14). The structures of these compounds were determined Accepted 11 May 2010 on the basis of extensive spectroscopic analyses and by comparison with the reported data in the liter- Available online 15 May 2010 ature. The inhibitory activities of compounds 1–12 against human tumor cell lines were evaluated,