Ginsenoside Rh2 suppresses growth of uterine leiomyoma in vitro and in vivo and may regulate ERαc-Srcp38 MAPK activity》.pdfVIP

J o u r n a l o f F u n c t i o n a l F o o d s 1 8 ( 2 0 1 5 ) 7 3 – 8 2 Available online at ScienceDirect journal homepage: /locate/jff Ginsenoside Rh2 suppresses growth of uterine leiomyoma in vitro and in vivo and may regulate ERα/c-Src/p38 MAPK activity Yan Zhu a,b,*, Junjiu Xu c, Zhao Li a,b, Shuwu Xie a,b, Jieyun Zhou a,b, Xiangjie Guo a,b, Xianying Zhou a,b, Guoting Li a, Ruihua Zhong a, Aying Ma a,d a Department of Reproductive Pharmacology, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Road, Shanghai 200032, China b NPFPC Key Laboratory of Contraceptives and Devices, Shanghai ETR Center of Reproductive Health Drug and Devices, 2140 Xie-tu Road, Shanghai 200032, China c Center for Drug Safety Evaluation and Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, No.501 Haike Road, Shanghai 201203, China d Fudan University, No.130 Dong-an Road, Shanghai 200032, China A R T I C L E I N F O A B S T R A C T Article history: Panax ginseng is widely used as a functional food in Asia because of its bioactivities. Here, Received 27 February 2015 we report that ginsenoside Rh2, an extract of red Panax ginseng, suppressed growth of uterine Received in revised form 23 June leiomyomas (ULs) in a rat model and decreased serum hormone levels in a dose-dependent 2015 manner. Rh2 also inhibited the growth of cultured human UL cells in vitro. After Rh2 treat- Accepted 24 June 2015 ment, cells showed morphological changes that were consistent with apoptosis. Using ELISA, Available online 14 July 2015 real-time RT-PCR, and W