《程书钧 院士 Lung Cancer— Molecular Network Disease》.pptVIP

* We analyzed 3 independent sets of glioma patients (371 samples) with the expression level of Embryfeature in their cancer tissues. Survival analysis showed that the prognosis of Embryfeature higher patients (H group, red line) was significantly worse than that of lower ones (L group, black line). * The expression level of Embryfeature was associated with the relapse-free and overall survival of the breast cancer patients, which was confirmed in 7 independent datasets, involving 1300 samples. Here the survival curves (K-M curve) of four datasets were shown. * * * Lung Cancer—Molecular Network Disease Cheng ShujunCancer Institute, Chinese Academy of Medical Sciences, Peking Union Medical College Fortune Magazine, March 22,2004 The five-year survival rate did not improve when a cancer has spread The challenge we faced in cancer therapy may be related to the complexity of gene network changes in lung cancer cells, especially at late stages. (Li Ding et al. Nature, 2008, Oct. 455: 1069-)DNA sequencing of 623 genes in 188 lung adenocarcinomas. 26 genes are mutated at significantly high frequencies . Several important pathway involved in lung adenocarcinoma A small-cell lung cancer genome with complex signatures of tobacco exposure/nature Published online 16 December 2009 . They sequenced a small-cell lung cancer cell line, NCI-H209, NCI-BL209 (an Epstein–Barr-virus-transformed lymphoblastoid line has been generated from the patient. ) to explore the mutational burden associated with tobacco smoking. A total of 22,910 somatic substitutions (including 134 in coding exons ) were identified in a small-cell lung cancer cell line . They estimated one mutation for every 15 cigarettes smoked. What we may learn from the recent studies: Pathway rather than individual genes appear to govern the course of tumorigenesis. The wide variation in tumor behavior and re