天然产物绝对构型的确定英文孔令义.pdfVIP

Chinese Journal of Natural Chinese Journal of Natural Medicines 2013, 11(3): 0193−0198 Medicines doi: 10.3724/SP.J.1009.2013.00193 Determination of the absolute configuration of natural products KONG Ling-Yi 1*, WANG Peng 1, 2 1 State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China 2 School of Pharmacy, Yancheng Teachers University, Yancheng 214002, China Available online 20 May 2013 [ABSTRACT] Structural elucidation of natural products is always one of the most important tasks for natural product researchers in related fields. Particularly, the absolute configuration (AC), being a great challenge for natural product chemists, has attracted much attention. During the past few decades, many techniques and approaches have been developed to determine the AC of natural products, including direct (or absolute) methods, e.g. X-ray diffraction (XRD), electronic and vibrational circular dichroism (ECD and VCD), and Raman optical activity (ROA), as well as indirect (or relative) methods using a reference or a derivatizing agent with known AC, e.g. CD with empirical rules and nuclear magnetic resonance (NMR) utilizing anisotropic effects of chiral derivatizing a