高危型HPVDNA检测在宫颈不典型鳞状细胞再分类中的意义.pdfVIP

肿瘤防治研究 2005 年第 32 卷第 11 期 7·33 · ·流行病学 · 高危型 H PV DN A 检测在宫颈不典型鳞状 细胞再分类中的意义 1 1 1 1 1 2 2 3 郭会芹 ,潘秦镜 ,李香菊 ,曹 　箭 ,张 　洵 ,章文华 ,吴令英 ,陈　凤 , 乔友林3 Role f or Highrisk HPV D NA Testing in Reclassif ication of ASC GU O Huiqin1 , PAN Qinj ing1 , L I Xiangj u1 , CAO J ian1 , ZHAN G Xun1 , ZHAN G Wenhua2 , WU Lingying2 ,C H EN Feng3 , Q IAO Youlin3 1. Cance r H osp i t al/ I ns ti t ute , Chi nese A ca demy of M e d ical S ciences an d Pek i ng Union M e d ical Uni ver s i ty , B ej i ng 10002 1 , Chi na , 2 . D ep a rtment of Gy necolori al N eop l as m , 3 . D ep ant ment of Ep i dem iology ( Cor resp on d i ng A ut hor) Abstract :Objective 　 To define the significance of highrisk human papillomavirus DNA ( HRHPV DNA) tes ting in reclassification of atypical squamous cell (A SC) , and p rovide scientific basis for it s clinical utility. Meth ods 　A total of 9034 women were enrolled in a cervical cancer screening p rogram in Shanxi China , in 2002 . In this p rogram , all subj ect s were examined by liquidbased cytology , HRHPV DNA testing and unaided visual inspection with acetic acid ( 5 %) . Of them , the cases of A SC with po sitive HPV DNA and negative HPV DNApo sitive unaided visual inspection were taken colpo scopic biop sy. We compared the incidence of cervical in traepithelial neoplasia (CIN) between the po sitive HPV DNA group of A SC and the negative HPV DNApo sitive unaided visual inspection group of A SC. Results 　There were 548 cases of A SC , who were taken colpo scopic bi op sy. Of the 548 cases ,333 (60 . 8 %) cases were HPV DNApo sitive , 2 15 (39 . 2 %) cases were negative HPV D