张仲景与吴鞠通方药的剂量功效关系比较研究.pdfVIP

( ) • 1009 • 中华中医药杂志 原中国医药学报 2011年5月第26 卷第 5 期 CJTCMP , May 2011, Vol . 26, No.5 ·论著· 张仲景与吴鞠通方药的剂量功效关系比较研究 李宇铭 （指导：姜良铎，李致重） （北京中医药大学第一临床医学院东直门医院，北京 100700） 摘要：常言“中医不传之秘在于量”，方药剂量一直是难以研究的课题。本研究将《伤寒论》、《金匮要 略》与《温病条辨》全部方药换算为克，输入数据库后制作出多种列表进行文献分析。结果发现，张仲景与吴鞠 通各自有14种药物，具有多层次的“剂量功效关系”，14种药物之中更有11种基本相同，具有可比性。再以桂枝 为例作分析，张仲景运用桂枝的用量与用法更为灵活多变，而吴鞠通在张仲景的基础上有所继承而发展。深入研 究其他药物，对於理论发展与临床应用均有重要意义。 关键词：张仲景；吴鞠通；伤寒论；金匮要略；温病条辨；剂量功效关系；剂量 Preliminary study on comparison of dose-effect relationship in formulas and medicinals between ZHANG Zhong-jing and WU Ju-tong LI Yu-ming (Director: JIANG Liang-duo, LI Zhi-zhong) (Dongzhimen Hospital, the First Clinical School Affi liated to Beijing University of Chinese Medicine, Beijing 100700, China) Abstract: As the saying goes, ‘the secret of Chinese Medicine is in the dosage’, the dosage of formulas and medicinals is always difficult to study. This research converted all the formulas and medicinal in Treatise on Cold Pathogenic Diseases, Synopsis of Golden Chamber and Detailed Analysis of Epidemic Warm Diseases into grams, entered into database and generate several tables for literature analysis. The results showed that, each of ZHANG Zhong-jing and WU Ju-tong had 14 types of medicines which having multi-level dose-effect relationship, and there were 11 types of medicine were basically the same among these 14 medicines, which showed their comparability. Using Guizhi as an example for analysis, ZHANG Zhong-jing was more fl exible in the dosage and usage in Guizhi, WU Ju-tong was inherit