多指标综合优选夏桑菊均质提取工艺研究.pdfVIP

广东药学院学报 　 Journal of Guangdong Pharmaceutical University　 Dec. 2014,30(6) 　 多指标综合优选夏桑菊均质提取工艺研究 1 2 2 2 1 肖俊勇 ,李曼莎 ,刘乡乡 ,宋力飞 ,龙晓英 (1.广东药学院 中药学院,广东广州 510006;2.广州泽力医药科技有限公司,广东 广州 510663) 摘要:目的基于均质提取技术优选夏桑菊复方的提取工艺。 方法 以单位药材提取物相对质量、干膏得 率、指纹图谱峰信息量为综合评分指标,选取乙醇体积分数、溶剂用量及提取温度为考察因素,采用正交 试验法优选夏桑菊提取工艺。 结果 最优工艺条件为:乙醇体积分数为30%,用量为45倍,提取温度为 70 ℃。 结论 在综合加权评分选定的工艺条件下,均质提取技术可高效快速地提取夏桑菊中的成分,优 选条件可指导高压差提取工艺。 关键词:均质提取技术;夏桑菊;多指标;高压差 中图分类号:R284.2　 文献标志码:A　 doi:10.3969/ j.issn.1006-8783.2014.06.005 文章编号:1006-8783(2014)06-0688-05 Study onthehomogenizationextractionofXiasangjubycomprehensiveevaluationof multiple indexes 1 2 2 2 1 XIAOJunyong ,LI Mansha ,LIU Xiangxiang ,SONG Lifei ,LONGXiaoying (1.School of Traditional Chinese Medicine,Guangdong Pharmaceutical Univercity,Guangzhou 510006, China;2.GuangzhouZeliPharmatech Co.,Ltd,Guangzhou510663,China) Abstract:Objective To optimize the extraction process for Xiasangju base on homogenization technology. Methods By using extract relative quality for per unit, the yield rate of dry extract, numbers of the fingerprint peaks as comprehensive evaluation indexes,extraction solvent,solvent volume and extraction temperature as factors, orthogonal test was used to optimize extraction process of Xiasangju.Results Optimum extraction conditions were as follows:45 times the amount of 30% ethanol and 70 ℃extraction temperature.Conclusion Undertheoptimumextractionconditions,homogenizationtechnology couldextract thefull detected composition of Xiasangju rapidly and efficiently,which could guide the high-pressure differential extraction process. Key words:homogenization technology;Xiasangju;multi-index evaluation;high pressure difference 　 　 夏桑菊颗粒是在经典名方“桑菊饮”的基础上 体的新型中药提取设备,具有提取效率高、过程稳