GC_FID法同步测定人含服速效救心丸后血中冰片_川芎嗪含量_郭军.pdfVIP

730 Chinese Traditional and Herbal Drugs34 8 2003 8 - GC FID 1 1 1 1 1 2 郭　军,黄　熙 , 王骊丽, 孟　华 , 张　莉 ,任　平 ( 1. , 710032; 2. , 710032) : , GC-FID , , 3 97 P 20420 ng/ mL,, , - , GC FID : ; ; - ; GC FID :R286. 1: A:0253 2670(2003)08 0730 03 - - Synchro determination of borneol and tetramethyl pyrazine in plasmaby GCFID for volunteers administrated with Suxiao Jiuxin Wan 1 1 1 1 1 2 GU Jun , HUANG Xi , WANG Li-li , MENG Hua , ZHANG Li , REN Ping ( 1. Research Center of TCM ; 2. Department of Geratology, Xijing Hospital, Fourth Military M edical University, Xian 710032, China) Abstract: bjectTo develop a method for pharmacokinetics detection of chemical component in healthy volunteers plasma administrated with Suxiao Jiuxin Wan, to provide the clinical experimental evi- dences for therapeutic drug monitoring (TDM) and the hypothesis of pharmacokinetics of traditional Chi- nese syndrome and recipe. MethodsA GC-FID method was established for rapid determination of borne- ol tetramethyl pyrazine T MP content in healthy volunteers plasma After obtaining the blood sample, ( ) . at different time the plasma concentration of borneol TMP was detected respectively T he data were, , , . 3 97 . processed with the software P to calculate thepharmacokinetics parameters Results A good linear re- lationshi