转录辅激活因子CBP在脂代谢中作用.pdfVIP

, 2006, 3 ( 5) : 387-390 JM edMo lBio,l 2006, 3 ( 5) : 387-390 CBP 苗春木, 赵蕾 综述 龚建平, 阮雄中 审阅 , 400010 CREB ( cAMP response elem ent bind ing protein b inding protein, CBP) , , 300, CBP, ( PPARCREBC /EBPs SREBPs) CBP, CBP CREB ( CBP); ; Q71 Function of Transcription Coactivator CBP in LipidM etabolism M IAO C unmu, ZHAO Le,i GONG Jianp ing, RUAN X iongz ong Center of Lpi id Metabolism Research, Chongqing University of M edical Sciences, Chongqing, 400010, China Department of epatobiliary Surgery, the SecondAff iliated osp ital of Chongqing University of M edi- calSciences, Chongqing, 400010, China Abstract CREB b ind ing protein ( CBP) is a crucial transcriptional coactivator, w ic contains ig ly conserved sequence and can interactw it about 300 kinds of transcription factors, and is con- sidered to be t e key point of t e regu lation of mammalian genes transcription1 CBP functions as acetyltransferase, bridge and scaffold in transcriptional activation1 T e study of lip idmetabolism as found t at several transcription factors related to lipidmetabolism, suc as PPAR, CREB, C /EBPs and SREBPs, w ere associated w it CBP1 So w e ypot esized t at CBP is t e key regulator of lip id metabolism1 Key words CBP; coactivator; lipidmetabolism [ 1] C rivia 1993 [ 3] CREB , , , CREB ( CREB-b ind ing protein, CBP ) CBP CBP, , [ 2] 1 CBP , 111 CBP : ( No130530360) CBP HATs, CBP : , , 1982, P300 : ( E-m ail: gongj ianping11@ otm ail1com ) T isw ork w as supported by a grant fro