抗菌肽耐药性研究进展.pdfVIP

微生物学通报 NOV 20, 2008, 35(11): 1786~1790 Microbiology © 2008 by Institute of Microbiology, CAS tongbao@ 专论与综述 抗菌肽耐药性研究进展 * 陈 福 罗玉萍 龚 熹 李思光 ( 330031) 摘 要: 抗菌肽是生物体产生的一类具有抵抗外源性病原体功能的小分子多肽 具有抗细菌、真 , 菌、病毒、癌细胞等多种活性。近几年的研究发现细菌会对抗菌肽产生耐药性。本文就细菌的构 成性耐药性机制和诱导性耐药性机制等研究进展进行综述。 关键词: 抗菌肽 构成机制 诱导机制 耐药性 , , , Mechanism of Antimicrobial Peptide Resistance * CHEN Fu LUO Yu-Ping GONG Xi LI Si-Guang (College of Life Sciences, Nanchang University, Nanchang 330031) Abstract: Antimicrobial peptides are a class of small peptides with anti-extrogenous pathogen activities. They are derived from organism and possess antibacterial, antifungus, antiviruses and anticancer cell actions. In recent years, it’s found that some microbial pathogens are able to resist antimicrobial peptides. The constitutive and inducible mechanism of a pathogen resists a given peptide were reviewed in this paper. Keywords: Antimicrobial peptides, Constitutive mechanism, Inducible mechanism, Resistance , , AMPs (AMPs, AMPs , [1] [2] AMPs Antimicrobial Peptides) [3] [4] [1] AMPs () AMPs, AMPs , AMPs (constitutive mechanisms of resistance)