多孔β-TCP生物陶瓷制备工艺技术进展.docVIP

多孔β-TCP生物陶瓷制备工艺技术进展 （ 武汉理工大学 材料学院 武汉 430070 ）【中图分类号】R318.08 摘要：人体骨组织的多孔结构, 有利于骨组织生长代谢所需物质的交流, 并能很好地适应外部应力的变化。合成模拟骨组织多孔结构的生物活性陶瓷材料, 用于临床人体骨组织缺失的修复, 是组织工程所需要的。多孔羟基磷灰石生物陶瓷是一种性能优异的人体硬组织修复材料 ,在植入界面后它具生物降解性 ,植入体内能逐步参与代谢以至最终与人体骨结合成一体 。多孔β-TCP生物陶瓷作为骨填充物、骨组织工程支架材料和药物载体的应用越来越广泛。目前，制备β-TCP多孔生物陶瓷的方法很多，其相应的制品都各有特色。本文主要阐述了多孔β-TCP成型方法，主要有发泡工艺、添加造孔剂工艺、有机泡沫浸渍工艺、注凝成型和微球堆积法成型以及多孔β-TCP生物陶瓷的现存问题和发展趋势. 关键词:多孔β磷酸三钙；生物陶瓷 ；成型工艺；工艺进展 Advances in production technology of Porous β-tricalcium phosphate(β-TCP)ceramicsHou wei （ Wuhan University of Technology Institute of Materials ,Wuhan 430070,China ） Abstract: The macroporous structure of human bone allow s the ingrowth of the soft t issues and organic cells into the bone matrix, profits the development and metabolism of bone t issue, and adapts the bone to the change of load . There is great requirement for artificial biomimicporous bioactive ceram ics with the similar structure of bone t issue that can be used clinically for repairing lost bone。Porous hydroxyapatite bioceramic is a good type of biomedical material which is used to restore and replace the hard tissue of human bodies . It is totally biocompatible and can form a direct bond with the neighbouring bone . Porous β-tricalcium phosphate(β-TCP)ceramics have many important biomedical applications，such as bone defect fillers，tissue engineering scaffolds and drug delivery systems．At present，there are many ways to pmpare porousβ-TCP ceramics，and the products prepared in different ways have different performance．The main methods of preparingβ-TCP powder had been formulated in this paper， including wet process，dry process and hydro-thermal method；Molded processes of porous β-TCP contained foaming process pore-creating process，organic foam dipping treatment process， injected and coagulated process and close-packed with microspheres method; the open questions at present and the trend of development of porousβ-TCP biological ceramics will also be explained. Key words : Porousβ-tricalcium phosp