制备缓释给药系统三维打印工艺参数的选定_余灯广.pdfVIP

1Š 1 1# 2 余灯广 , 申夏夏 , 朱利民 , 杨祥良 ( 1 1 东华大学化学化工与生物工程学院, 上海市 201620; 2 1 华中科技 大学生命科学与技术学院, 武 市 43 0074) R943 A 1001- 0408(2008) 31- 243 7-04 目的: 选择制备缓释给药系统的合适的三 打印成形工艺参数, 为缓控释给药系统的研发提供新的策略和途径方法: 通 过自设试验选择合适的粉末粒径打印液溶剂喷涂层间隔时间;通过滴试验线试验和条带试验确定喷涂滴间距线间距及喷涂次 - 2 数;制备给药系统,通过硬度脆碎度和体外溶出试验进行评价结果: 所制备给药系统硬度为4181 kg # cm 脆碎度为0157%, 药 物连续释放 11 h, 具有较好的机械性能和缓释效果结论: 所建立方法简单有效易行, 可为三 打印工艺的进一步应用提供参 考 三 打印; 给药系统; 工艺参数; 机械性能;缓释 Selecting of 3DP Parameters for Fabri cating Sustained- release DDS YU Den - uan , SHEN ia - xia, ZHU Li- min(Colle e of Chemistr , Chemical En ineerin and g g g g y g g Biotechnology, Donghua University, Shanghai 20 1620, China) YANG ian - lian (Colle e of Life Science and T echnolo , Huazhon Universit of Science and T ech- g g g gy g y nology, Wuhan 4300 74, China) ABSTRACT OBJECT IVE:T o select arameters for re arin dru deliver s stems ( DDS) usin three- dimensional rint- p p p g g y y g p in ( 3DP) to su l new methods and asswa for the sustained and controlled release DDS1 METHODS: T he diameters of g pp y p y articles, the t e of solvents and the time intervals between two rintin la ers were determined b self- ro osed methods1 p yp p g y y p p The drop- to- drop spacing, the line- to- line spacing and printing passes were choosed based on the drop tests, line and ribbon tests1 The mechanical performance of the DDS was evaluated through hardness , friability tests and the in vitro dis-