II型毛玻璃肝细胞是慢性乙型肝炎肝细胞癌的一个标志.pdfVIP

Human Pathology (2013) 44, 1665–1671 /locate/humpath Original contribution Type II ground-glass hepatocytes as a marker of hepatocellular carcinoma in chronic hepatitis B☆ a b c Alka Mary Mathai MD, DNB , Jacob Alexander MD, DM , Fang-Ying Kuo MD , Michael Torbenson MD d, Paul E. Swanson MD a, Matthew M. Yeh MD, PhD a,b,⁎ aDepartment of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA bDepartment of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA cDepartment of Pathology, Chang-Gung Memorial Hospital Kaohsiung Medical Center, Chang-Gung University College of Medicine, 833 Tao-Yuan, Taiwan dDepartment of Pathology, the Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Received 21 October 2012; revised 27 January 2013; accepted 30 January 2013 Keywords: Summary Ground-glass hepatocytes are seen in chronic hepatitis B virus (HBV) infection and are Hepatocellular carcinoma; known to harbor pre-S mutants, which are implicated in the pathogenesis of hepatocellular carcinoma Hepatitis B virus (HCC). However, the association between ground-glass hepatocytes and HCC has yet to be clearly infection; elucidated. The aim in the present study was to investigate the association of ground-glass hepatocytes Hepatitis B surface with (1) the histologic characteristics of HBV-related HCC and (2) the grade of inflammation, stage of antigen;