食管胃交界处腺癌的临床研究进展.pdfVIP

120 中国肿瘤临床2015年第42卷第2期 ChinJClinOncol2015,Vol.42,No.2 · · 综 述 食管胃交界处腺癌的临床研究进展 王 龙 张 雪 综述 刘 巍 审校 摘要 食管胃交界处腺癌（adenocarcinomaofesophagogastricjunction，EGJA）有其独特的解剖学位置，同时又位于鳞状上皮 与柱状上皮交界之处，其生物学特性不同于食管癌和胃癌，诊断分型一直存在众多的争议，治疗模式在学术界也始终没有公认的 “金标准”，特别是局部进展期EGJA的治疗策略更是难以抉择。随着影像学技术的发展和各项大型临床研究结果的公布，EGJA 的治疗日益个体化，同时也凸显了多学科协作的重要性。本文将针对以上问题对EGJA的最近进展做一综述。 关键词 胃食管交界处腺癌 治疗 诊断 进展 doi:10.3969/j.issn.1000-8179 Clinical research progress in adenocarcinoma of the esophagogas- tric junction Long WANG, Xue ZHANG, Wei LIU Correspondence to: Wei LIU; E-mail: newhebeiliuwei@163.com Department of Medical Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China Abstract The adenocarcinoma of the esophagogastric junction (EGJA) is located in a unique anatomical position and at the junction of the squamous epithelium and the columnar epithelium. The biological characteristics of this disease are different from those of esophageal or gastric cancer. The diagnostic classification of EGJA has been subject to controversies, and no gold standard therapeu- tic regimens have been established, especially in the choice of treatment of locally advanced EGJA. Results from large-scale clinical tri- als and imaging technology development showed that the treatment of EGJA has been individualized. Furthermore, this problem high- lights the importance of multidisciplinary collaboration. This article focuses on current progress in studies on EGJA. Keywords: adenocarcinoma of esophagogastric junction, treatment, diagnosis, progress 食管胃恶性肿瘤是一种颇具挑战性的疾病，特 标准进行了研究。研究人员按照第七版AJCC食管 别是食管胃交界部腺癌（adenocarcinomaofesophago⁃ 癌及胃癌TNM分期标准分别对163例患者进行分 gastricjunction，EGJA）近些年来发病率增长迅速，但 期。结果发现根据胃TNM分期标准，预后风险呈逐 是对于其诊断分型和治疗策略选择上的规范化还远 步增加趋势，Ⅱ期与Ⅲ期患者生存率曲线出现明显 远做不到，在具体的临床诊治层面，同一国家、地区， 分离（P=0.