参苓白术散加减对例痰湿质脑梗塞患者的二级预防研究.docVIP

参苓白术散加减对102例痰湿质脑梗塞患者的二级预防研究 焦久存 王彩娟 魏晓珊 指导老师：吕士君 河北省石家庄市中医院 [摘　要]　【目的】 观察参苓白术散加减对痰湿质脑梗塞二级预防的疗效及其安全性。【方法】 将102例痰湿质脑梗塞恢复期患者按先后顺序随机分为观察组51例和对照组51例。两组在常规治疗的基础上,观察组予参苓白术散加减辩证治疗6个月,同时给予口服阿司匹林;对照组给予口服阿司匹林；两组均随访6个月。比较两组患者缺血性脑卒中复发率、临床神经功能缺损、日常生活活动能力和中医症状评分的改善情况以及中药辩证施治的安全性。【结果】 观察组和对照组的复发率,两组差异有统计学意义(Ｐ0.05)；改善临床神经功能缺损评分、日常生活活动能力评分、中医症状评分方面,观察组优于对照组(Ｐ≤0.01)；均未出现严重不良反应。【结论】 参苓白术散加减对痰湿质脑梗塞恢复期二级预防有一定的疗效,是临床预防脑梗塞安全有效的方法之一。 [关键词]　 脑梗塞；痰湿质；二级预防；参苓白术散；阿司匹林 Clinical observation on therapeutic effect of for the secondary prevention of Tanshi constitution type’s ischemi cerebral apoplexy Jiao-jiucun,Wangcaijuan,Wei-xiaoshan，Teacher Lv-shijun Shijiazhuang Hospital of TCM, Shijiazhuang 050051,Hebei,China Abstract: Objective: To observe the therapeutic effect and safety of Shenlingbaizhusan for the secondary prevention of Tanshi constitution type’s ischemic cerebral apoplexy. Methods: One hundred and two cases of Tanshi constitution type’s ischemic cerebral apoplexy were randomly divided into an observation group and a control group according to the visiting sequence(51,51). Both groups were treated on the bases of the routine treatment, the observation group was treated with Shenlingbaizhusan combined with oral administration of Aspirin for six months. The control group was treated with oral administration of Aspirinal one. Six month follow up was done in two groups. Then the recurrence rate of ischemic cerebral apoplexy, the improvement of neurologic impairment, activity of daily living and TCM symptom scores and the safety between two groups were compared. Results: There was significant difference between two groups (Ｐ0.05).The observation group was superior to the control group in improving the scores of the nerrologic impairment, activity of daily living and TCM symptom (Ｐ0.01,Ｐ0.001). There was no severe adverse reaction in two groups except 1 cases of gastrointestinal reaction caused by oral administration of Aspirin in control group. Conclusion: Shenlingbaizhusan has a certain