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Molecular and Cellular Endocrinology 356 (2012) 2–12 Contents lists available at SciVerse ScienceDirect Molecular and Cellular Endocrinology journal homepage: www.else /locate/mce Review The ovarian reserve in mammals: A functional and evolutionary perspective a,b,c,d,⇑ e f a,b,c,d a,b,c,d Philippe Monget , Julien Bobe , Alain Gougeon , Stéphane Fabre , Danielle Monniaux , Rozenn Dalbies-Tran a,b,c,d a INRA, UMR85, Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France b CNRS, UMR6175, F-37380 Nouzilly, France c Université de Tours, F-37041 Tours, France d IFCE, F-37380 Nouzilly, France e Différenciation sexuelle et ovogenèse, INRA, SCRIBE UR1037, Campus de Beaulieu, F-35000 Rennes, France f INSERM U-1052 et ANIPATH, Faculté de médecine Laennec, 7 rue Guillaume Paradin, 69732 Lyon Cedex 08, France a r t i c l e i n f o a b s t r a c t Article history: The constitution and the control of the ovarian reserve is of importance in mammals and women. In par- Available online 5 August 2011 ticular, the number of primordial follicles at puberty is positively correlated with the number of growing follicles and their response to gonadotropin treatments. The size of this ovarian reserve depends on genes Keywords:
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