基于磁刺激内关穴脑电α波时频分析.docVIP

基于磁刺激内关穴的脑电α 波时频分析 摘要：磁刺激技术由于具有无创性和有效性，近年来在神经生理学和临床等方面得到了广泛的应用，与传统针灸作用有着异曲同工之处。本文将磁刺激和传统中医穴位、经络传导相结合，通过应用Gabor 小波和希尔伯特变换方法分析磁刺激内关穴的脑电数据，研究了磁刺激对大脑α 节律能量分布的影响。分析结果显示，磁刺激内关穴后大脑额叶和左侧枕叶α 波的能量明显高于刺激前。α 波代表了中枢神经系统的一种被动状态，α 波的出现或增强说明人处于清醒、安静的状态，提示磁刺激内关穴能够起到安神、醒脑的功效，这也正好与内关穴的功能相符。 关键词：磁刺激；Alpha 波； Gabor 小波；希尔伯特变换 中图分类号 R318 文献标识码 A The Time-frequency Analysis of alpha wave Based on EEGunder Magnetic Stimulation at Acupoint of Neiguan(PC6) LI Wen-Wen XU Gui-Zhi* CHEN Xiao-Gang YANG Shuo YU Hong-Li(Department of Biomedical Engineering, School of Electrical Engineering, Hebei University of Technology,Tianjin 300130) Abstract： Magnetic stimulation as a non-invasive and efficient technique has been applied broadly in neurophysiology and clinical practice. And it has similar effects with acupuncture. This articlecombined magnetic stimulation and traditional Chinese medicine acupuncture points、meridiansconduction. Gabor wavelet transform and Hilbert transform are used to analysis the EEG data which was under magnetic stimulation at Neiguan point. The effect of magnetic stimulation on α wave energy distribution was studied. The results showed that the power of α wave in the frontal and left occipital brain after magnetic stimulation was significantly higher than that before stimulation. Alpha wave represents a passive state of the central nervous system, and its appearance or enhancement shows that people are sober and quiet. The study prompted that magnetic stimulation at acupoint of Neiguan could play the effect of calm and tranquilization. This also coincided with the function of Neiguan point. Key words：Magnetic stimulation; Alpha wave; Gabor wavelet; Hilbert transform 1 引言 磁刺激是利用变化的磁场无接触地通过空间耦合使组织内部形成感应电流，刺激组织细胞，从而引发细胞动作电位的一门技术。磁刺激首先由Kolin 于1945 年从青蛙的肌肉神经标本得到证明，他展示了用带磁的磁极片包裹坐骨神经会使其产生搏动，并记录到肌肉收缩。1985 年，Baker等人将平面线圈置于正常人运动区的头皮上，观察到手肌抽动，首次在人体上实现了大脑皮层中枢神经刺激。1990 年Cohen 等人证明了不同放置的磁刺激线圈对大脑皮层刺激时会引起不同手指活动。近几十年来，磁刺激以其安全、无痛、无创、易于操作等优点，与传统针灸作用有异曲同工之处，成为生物医学工程和神经电生理研究的一个新热点[1~2]。穴位是中医针灸调控神