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Why study virus-host interaction To elucidate structural and biological properties of viruses and their pathogenesis To develop novel diagnosis, prophylaxis and therapies for viral diseases To predict future outbreak of viral pandemics To gain insights into cellular machineries To manipulate and utilize viruses as gene transfer vectors Methods for study ligand-protein interaction Increasing complexity Virus metagenomics and ecosystem Nature Rev Microbiol 2005, p504 New and reemerging viruses Annual Rev Microbiol 2005 Thank you! Virus-host interaction 病毒与宿主的相互作用 复旦大学 医学院医学分子病毒学重点实验室、生物医学研究院 谢幼华 yhxie@ 2010.9.9 病毒和宿主的相互作用是分子病毒学研究的 最重要主题之一 在微观和宏观层次上理解病毒和宿主的相互 作用 Order (5) Family Subfamily Genus Species -virale Adenoviridae -virinae Mastadenovirus Human adenovirus C Order (5) Family Subfamily Genus Species -virale Hepadna- viridae -virinae Orthohepadna- virus Human Hepatitis B Virus Order (5) Family Subfamily Genus Species -virale Retroviridae Ortho- retrovirinae Lentivirus Human Immunodeficiency Virus-1 (HIV-1) Nature Review Microbiology 2008 Order (5) Family Subfamily Genus Species -virale Orthomyxo- viridae -virinae Influenzavirus A Influenza A virus Nature Review Microbiology 2008 Viruses are obligatory intracellular parasites Viruses multiply inside cells by expressing and replicating their genomes. Viruses need the following cellular machinery: Enzyme systems that synthesize amino acids, nucleotides, carbohydrates and lipids; Enzyme systems that generate energy; Systems that synthesize proteins Membranes Virus classification by International Committee on the Taxonomy of Viruses (ICTV) “a virus species is a polythetic class of viruses that
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