盐酸去甲万古霉素结膜下注射的眼表安全性评估.docVIP

 盐酸去甲万古霉素结膜下注射的眼表安全 性评估 毛奕茜1，郑燕林2，高明敏1** 5 10 15 20 25 30 35 40 45 （1. 成都中医药大学研究生学院，成都 610075； 2. 成都中医药大学附属医院眼科，成都 610075） 摘要：目的 评估内眼手术后结膜下注射盐酸去甲万古霉素的眼表安全性。方法 采用前瞻性 非随机对照临床试验，将 64 例（均为单眼）内眼手术后患者分为 A、B 两组，A 组结膜下 注射 10mg 去甲万古霉素（n=33），B 组结膜下注射 20mg 去甲万古霉素（n=31），比较观 察 A、B 两组术后第一天及术后一周的眼表情况。结果 术后第一天 A、B 两组均出现结膜 下水肿及出血，B 组发现 15 例结膜下黄白色颗粒状药物残留。其结膜下水肿高度分级 1 级 A 组 24 例，B 组 14 例，2 级 A 组 8 例，B 组 13 例，3 级 A 组 1 例，B 组 4 例，A 组结膜 下水肿程度比 B 组轻（P0.05）；结膜下水肿面积 A 组（74.58±20.050）mm2，B 组（89.42 ±16.998）mm2 ，两组间比较差异有统计学意义（P0.05）；结膜下出血面积 A 组（75.97 ±16.423）mm2 ，B 组（87.32±13.828）mm2，两组间比较差异有统计学意义（P0.05）。 术后一周 A、B 两组结膜下水肿消失，结膜下出血明显减轻，B 组结膜下颗粒状药物完全吸 收。结论 去甲万古霉素结膜下注射眼表安全，10mg 眼表安全性更高。人称做主语，不与正 文语句重复。一般研究性文章：以摘录要点的形式按目的、方法、结果、结论的结构报道出 作者的主要研究成果，字数在 200～400 字左右为宜，不用第一人称做主语，不与正文语句 重复。 关键词：去甲万古霉素；结膜下注射；眼表安全性 中图分类号：R777.39 Ocular surface safety assessment of subconjunctival injecting Norvancomycin Hydrochloride MAO Yixi1, ZHENG Yanlin2, GAO Mingmin1 (1. Postgraduate School,Chengdu University of TCM,Chengdu 610075; 2. Department of Ophthalmology,Hospital of Chengdu University of TCM,Chengdu 610075) Abstract: Objective Present study was to assess the ocular surface safety of Subconjunctival injecting Norvancomycin Hydrochloride after intraocular surgery. Methods A prospective non-random clinical study was performed in 64 cases(ocellanae)，who received intraocular surgery in our hospital. Patients were divided into A and B group. A group was Subconjunctival injected 10mg Norvancomycin(n=33),B group was injected 20mg(n=31).The ocular surface of two groups were observed in the first day and one week after intraocular surgery. Results Two groups occurred subconjunctival edema and Subconjunctival hemorrhage in the first day，and B group appeared 15 cases Subconjunctival medicine residue who were yellow and white. The height of subconjunctival edema was divide 3 level.1 level included 24 cases in the A group and 14 cases in the B group ；2 level include 8 cases in the A group and 13 cases in the B group；3