Circadian autophagy rhythm英语.pdfVIP

Review Circadian autophagy rhythm: a link between clock and metabolism? Di Ma1,2, Siming Li1,2, Matthew M. Molusky1,2 and Jiandie D. Lin1,2 1 Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA 2 Department of Cell and Developmental Biology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA Nutrient and energy metabolism in mammals exhibits a Transcriptional profiling revealed that a large number of strong diurnal rhythm that aligns with the body clock. genes involved in glucose and lipid metabolism are tempo- Circadian regulation of metabolism is mediated through rally controlled [12–16]. Recent chromatin-immunoprecip- reciprocal signaling between the clock and metabolic itation sequencing studies support the notion that many of regulatory networks. Recent work has demonstrated these rhythmically expressed genes are direct transcrip- that autophagy is rhythmically activated in a clock-de- tional targets of clock genes, such as Bmal1 and Rev-erba pendent manner. Because autophagy is a conserved [17,18]. Clock exerts its physiological effects in part biological process that contributes to nutrient and cell- through these direct transcriptional targets. For example, ular homeostasis, its cyclic induction may provide a diurnal regulation of xenobiotic detoxification is mediated novel link between clock and metabolism. This review through the circadian PAR-domain basic leucine zipper discusses the mechanisms underlying circadian auto- transcription factors DBP/TEF/HLF, all of which are clock phagy regulation, the role of rhythmic autophagy in targets [6]. Hepatic lipogenesis and lipoprotein secretion nutrient and energy metabolism, a