血清胱抑素C、β2微球蛋白与缺血性脑小血管病的相关性研究.docx

血清胱抑素C、β2微球蛋白与缺血性脑小血管病的相关性研究

丁联斌方麒林刘团结王博沈滔毛蕾徐玉萍吉莉苏云楠

[关键词]?脑小血管病；血清胱抑素C；β2-微球蛋白

[中图分类号]?R743??????[文献标识码]?A??????[DOI]?10.3969/j.issn.1673-9701.2024.11.008

Study?on?the?correlation?between?cystatin?C，?microglobulin?and?ischemic?cerebral?small?vessel?disease

DING?Lianbin，?FANG?Qilin，?LIU?Tuanjie，?WANG?Bo，?SHEN?Tao，?MAO?Lei，?XU?Yuping，?JI?Li，?SU?Yunnan

Department?of?Neurology，?Wusong?Hospital?of?Zhongshan?Hospital?Affiliated?to?Fudan?University，?Shanghai?200940，?China

[Abstract]?Objective?To?explore?the?the?correlation?between?cystatin?C?（Cys?C），?beta-2?microglobulin?（β2-MG）?and?ischemic?cerebral?small?vessel?disease?（CSVD）?and?its?subgroups.?Methods?Totally?234?patients?with?CSVD?were?assigned?to?the?study?group，and?92?elderly?people?with?no?abnormal?findings?in?head?MRI?were?selected?as?controls.The?CSVD?patients?were?further?divided?into?the?subgroups?of?lacunar?infarction?（LI），white?matter?lesion?（WML）?and?LI+WML.?Each?group?was?compared?risk?factors?include?the?blood?level?of?Cys?C?and?β2-MG.?Results?There?were?statistically?significant?differences?between?CSVD?group?and?control?group?in?cystatin?C?（Cys?C）?and?β2-MG?（P0.05）.?Cystatin?C?（Cys?C）?and?β2-MG?there?were?statistically?significant?differences?between?WML?group?and?control?group?（P0.05），?and?also?between?WML+LI?group?and?control?group?（P0.05）.?Logistic?regression?analysis?and?comparison?across?subgroups?showed?Cys?C?and?β2-MG?to?be?the?common?risk?factors?for?WML?group?and?WML+LI?group?inpatients?with?ischemic?cerebral?small?vessel?disease.?Conclusion?Cys?C?and?β2-MG?are?the?common?risk?factors?for?WML?group?and?WML+LI?group?inpatients?with?ischemic?cerebral?small?vessel?disease.The?risk?factors?vary?across?different?CSVD?subgroups.

[Key?words]?Cerebral?small?vessel?disease;?Cystatin?C;?β2-microglobulin

1??资料与方法

1.1??一般资料

1.2??研究方法

1.3??统计学方法

采用SPSS?26.0统计软件对数据进行处理分析，计量资料以均数±标准差（）表示，组间比较采用?t?检验；数资料以例数（百分率）表示，组间比较采用χ2检验，亚组间比较采用方差分析或Kruskal-Wallis检验（资料不符合正态分布）；采用多因素Logistic回归模型分析CSVD及其亚组的危险因