Remdesivir-maleate-GS-5734-maleate-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Remdesivirmaleate

Cat.No.:HY-104077A

CASNo.:2250110-53-1

Synonyms:GS-5734maleate

分⼦式:C₃₁H₃₉N₆O₁₂P

分⼦量:718.65

作⽤靶点:DNA/RNASynthesis;SARS-CoV

作⽤通路:CellCycle/DNADamage;Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Remdesivirmaleate(GS-5734)是⼀种核苷类似物，具有抗病毒活性，对SARS-CoV及其4种变体alpha、

beta、gamma和delta的EC50值分别为3.3μM,4.7μM,32μM,3.7μMand9.2μM。Remdesivir

maleate有潜⼒⽤于2019-nCoV(COVID-19)研究。

客户使⽤本产品发表的科研⽂献

•NEnglJMed.2023Jan5;388(1):89-91.

•Science.2021Nov26;374(6571):1099-1106.

•Science.2020Jun26;368(6498):1499-1504.

•Nature.2021May;593(7859):418-423

•Nature.2020Jun;582(7813):561-565.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

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ProofreadingExoribonuclease.MBio.2018Mar6;9(2).pii:e00221-18.

[2].WangM,etal.Remdesivirandchloroquineeffectivelyinhibittherecentlyemergednovelcoronavirus(2019-nCoV)invitro.CellRes.

2020Mar;30(3):269-271.

[3].HuH,etal.OptimizationoftheProdrugMoietyofRemdesivirtoImproveLungExposure/SelectivityandEnhanceAnti-