免疫学概述 (英文).pptx

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Immunity1.Immunity:referstoallmechanismsusedbythebodyasprotectionagainstenvironmentalagentsthatareforeigntothebody.(torecognizeandeliminateforeignsubstances)2.Agents:microorganisms(viruses,bacteriaetc)andtheirproducts,foods,chemicals,pollen,tumorcells,etc.3.Immunesystem:immunetissuesandorgans,immunecells,immunemoleculesIntroduction

Threefunctionsofimmunesystem:(1)immunologicdefence(2)immunologicsurveillance(3)immunologichomeostasis

TheDangerModel:ARenewed

SenseofSelfPollyMatzinger

TheSelf-NonselfModelsTheInfectious-Nonself(INS)ModelTheDangerModel

ImmuneResponseIntroductionInnateimmuneresponsenaturalimmuneresponsenon-specificimmuneresponseAdaptiveimmuneresponseacquiredimmuneresponsespecificimmuneresponse

InnateimmunityItreferstoanyinbornimmunitythatisalreadypresentthefirsttimeapathogenisencountered.Itdoesnotrequirepriorexposureandisnotmodifiedsignificantlybyrepeatedexposurestothepathogenoverthelifeofanindividual.Introduction

Theprincipalmechanismsofinnateandadaptiveimmunity

InnateimmunitymechanismofrecognitionPathogenassociatedmoleculespatterns(PAMPs):LPS,DNA,RNA,ProteinDanger-associatedmolecularpatterns(DAMPS):DNA,HSPPatternrecognitionreceptors(PRR):Toll-likereceptor(TLR),C-lectinrecptor(CLR),RIG-I-Likerecptor(RLR),NOD-likeReceptor(NLR)

Toll-likereceptor(TLR)

TLR

InnateimmuneresponseIntroductionMacrophageAttackingE.coli

AdaptiveimmuneresponseTheTcellsandBcellsinthebodyrecognizetheantigenand,inturn,becomeactivated.Theactivatedlymphocytesthenproliferateandcarryouttheirspecificeffectorfunctions.

TypesofadaptiveimmunityTwotypesofadaptiveimmunityHumoralimmunity:mediatedbyBcellsanddefenseagainstextracellularmicrobes.Cell-mediatedimmunity:mediatedbyTcellsanddefenseagainstintracellular

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