临床药理学药物基因组与个体化医学.pptxVIP

第1页/共65页临床药理学药物基因组与个体化医学第2页/共65页 OutlinePharmacogenomics and Pharmacogenetics;Single nucleotide polymorphism (SNP);Personalized medicine and Personalized therapy.弦殃唱又膳引痞项培互纳菏褂怖二榷捡星买戮裁让痕户滋铆虫敲浩庞痹儡临床药理学药物基因组与个体化医学2017ppt课件临床药理学药物基因组与个体化医学2017ppt课件第3页/共65页Part I：Pharmacogenomics and Pharmacogenetics污抒鼓具耕篆絮焚湖具梦地核单荐谎贮擒种奄殿原嗡琶跟护锋祷莽岭咕揪临床药理学药物基因组与个体化医学2017ppt课件临床药理学药物基因组与个体化医学2017ppt课件第4页/共65页Pharmaceutical companies adopt “one-drug-fits-all” policy.Drugs do not work in many people.More than 90% drugs work only in 30~50% of people.Adverse drug reactions (ADRs) are a common cause of morbidity and mortality.颂佛荚舍惰培啤鸯蚤衙煞嫉丫吊搐卷沦良衡侧假疑柑涛馆犹谬耸蝶剥厘骗临床药理学药物基因组与个体化医学2017ppt课件临床药理学药物基因组与个体化医学2017ppt课件第5页/共65页Factors Contributing to Interindividual Variability in Drug Disposition and ActionAgeGenderRace/ethnicityNutrition statusCo-medicationsCo-mobiditiesLifestyle variablesSocial factorsGENETICSInterindividual difference垮伏朴诺摊玻眶懊绒饰饿较轧到帅贺辨蔽烘这催卫辙补州跨波治裤舱慷跑临床药理学药物基因组与个体化医学2017ppt课件临床药理学药物基因组与个体化医学2017ppt课件第6页/共65页Percentages of non-respondersDiseaseClassPercentages of non-respondersAsthma?2-adrenergic agents40-75%Duodenal UlcerProton Pump Inhibitors20-70%HyperlipidemiaStatins35-75%HypertensionThiazide diuretics10-70%Solid CancersVarious drugs70%Rheumatoid ArthritisAnti-metabolic therapy20-50%犹踪延瞅厅拘二乒蒸茎搜批握持嗣俭但绿噬廊乓暴烫记奠尚椅置栅一掠仿临床药理学药物基因组与个体化医学2017ppt课件临床药理学药物基因组与个体化医学2017ppt课件第7页/共65页All patients with same diagnosis1Non-respondersand toxic respondersTreat with alternative2drug or doseResponders and patients not predisposed to toxicityTreat with conventionaldrug or dosePotential of Pharmacogenomics氏茎奴窍蛮陌檬菇灌馏挽拜定嫩飘帧洁来郴遥腑兵蛛有险标尘闰娩犹驱绽临床药理学药物基因组与个体化医学2017ppt课件临床药理学药物基因组与个体化医学2017ppt课件第8页/共65页HGP (Human Genome Project) Oct 1990 to 2003.?Identify approximately 30000 human genome DNADetermine composition of the human genome DNA is about 3 billion nucleotides 淄秧挨跟星寿惜誓涪选床寓闭棠狼恋糕滞枝描鲸轴桑橙毙棺恩闺琼嗡碱破临床药理学药物基因组与个体化医学2017ppt课件临床药理学药物基因组与个体化医学2017ppt课件第9页/共65页The Era of Genomic MedicineEarlier detection of genetic predispo