利用酶作为调节肠道微生物群的有力工具.pdfVIP

TIMI 2056 No. of Pages 4 Trends in Microbiology Forum Exploiting enzymes as a biochemical reactions. In the livestock by the ecological networks of microbes industry, various enzymes have been in the gut. Enzymes can also stimulate gut powerful tool to added extensively to feed, managing to microbial growth by catalyzing the removal modulate the gut promote the growth of the animals. Their of harmful chemicals. The administration of beneficial effects are associated with, and intestinal alkaline phosphatase (IAP), an microbiota may in part be ascribed to, a change in endogenous enzyme secreted by intestinal Xiaoyun Su1,* and Bin Yao 1,* gut microbiota, strongly suggesting that epithelial cells, promoted the growth of enzymes can be deliberately selected to specific gut microbes by reducing the con- modulate the gut flora [2]. Indeed, in mice centration of luminal nucleotide triphos- and other experimental animals, enzymes phates inhibitory to bacteria. This is strongly Orally administered enzymes can have undoubtedly been proved to potently related to attenuating gut barrier lesions have profound effects on the com- influence the gut microbiome [3–8]. and alleviating diseases such as alcohol- position of the gut microbiota and induced hepatosteatosis [6]. may serve as an appealing alterna- The ways in