微生物群介导的定植抵抗：机制和调控.pdfVIP

nature reviews microbiology /10.1038/s41579-022-00833-7 Review article Check for updates Microbiota-mediated colonization resistance: mechanisms and regulation Gustavo Caballero-Flores   1,2 , Joseph M. Pickard1,2 Gabriel Núñez   1 Abstract Sections A dense and diverse microbial community inhabits the gut and many Introduction epithelial surfaces. Referred to as the microbiota, it co-evolved with the Direct mechanisms host and is benefcial for many host physiological processes. A major Prokaryotic antimicrobial function of these symbiotic microorganisms is protection against peptides pathogen colonization and overgrowth of indigenous pathobionts. Indirect mechanisms Dysbiosis of the normal microbial community increases the risk of Pathogen evasion of pathogen infection and overgrowth of harmful pathobionts. The colonization resistance protective mechanisms conferred by the microbiota are complex Conclusions and future and include competitive microbial–microbial interactions and perspectives induction of host immune responses. Pathogens, in turn, have evolved multiple strategies to subvert colonization resistance conferred by the microbiota. Understanding the mechanisms by which microbial symbionts limit pathogen colonization should guide the development of new therapeutic approaches to prevent or treat disease. 1 Department of Pathology and Rogel Cance